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B'luru scientists explore potential cure for Alzheimer’s Disease using microRNAs

The study published in the journal NAR Molecular Medicine has unveiled various miRNA-mRNA pathway networks altered in Alzheimer's, which could potentially reveal various pathways to target for drug development

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Image for representational purpose only. Photo Courtesy: istock

Image for representational purpose only. Photo Courtesy: istock

MicroRNAs (miRNAs) -- the discovery of which received the Nobel Prize in Physiology or Medicine last year -- may play a significant role in the treatment and cure of Alzheimer's Disease (AD), said researchers from Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR). 

Alzheimer's Disease is a devastating condition that steals away mental faculties and debilitates day-to-day life of patients. Characterised by the accumulation of protein clumps in the brain, memory loss, and cognitive deficits, it is estimated to affect more than 57.4 million people worldwide, a number that is expected to almost triple to 152.8 million cases by 2050.

Addressing this, researchers from JNCASR, an autonomous institute of the Department of Science and Technology (DST), explored altered miRNAs in the Alzheimer's brain for early, specific, and accurate clinical diagnosis of the condition.

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