Updated On: 26 July, 2025 10:58 AM IST | New Delhi | IANS
Researchers have found that glipizide was linked to a higher incidence of heart failure, related hospitalisation, and death compared to dipeptidyl peptidase-4 (DPP-4) inhibitors

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A commonly used type 2 diabetes medication in the US -- Glipizide -- may be linked to a higher rate of heart-related conditions, claimed a study.
Researchers from Mass General Brigham examined nationwide data from nearly 50,000 patients treated with different sulfonylureas. They found that glipizide was linked to a higher incidence of heart failure, related hospitalisation, and death compared to dipeptidyl peptidase-4 (DPP-4) inhibitors. The findings are published in JAMA Network Open.
“Patients with type 2 diabetes are at heightened risk of adverse cardiovascular incidents such as stroke and cardiac arrest,” said corresponding author Alexander Turchin, Division of Endocrinology at Brigham and Women’s Hospital (BWH).